Synthesis, spectral characterizations and antimicrobial activity of some Schiff bases of 4-chloro-2-aminophenol
Bulletin of the Chemical Society of Ethiopia, cilt.25, sa.3, ss.407-417, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 3
- Basım Tarihi: 2011
- Dergi Adı: Bulletin of the Chemical Society of Ethiopia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.407-417
- Anahtar Kelimeler: Schiff base, 4-Chloro-2-aminophenol, Antimicrobial activity, INTRAMOLECULAR PROTON-TRANSFER, MANNICH-BASES, SOLID-STATE, METAL-COMPLEXES, FT-IR, BIOLOGICAL-PROPERTIES, ABSORPTION-SPECTRA, CRYSTAL-STRUCTURES, HYDROGEN-BOND, AB-INITIO
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
A series of 4-chloro-2-[(arylmethylidene)amino]phenols (1-11) including methoxy group were synthesized using appropriate synthetic route. The structures of the Schiff bases were characterized by FT-IR, UV-Vis, ESI-MS, 1H and 13C-NMR spectroscopic techniques and analytical methods. A relation is observed between melting points and existence of intramolecular hydrogen bonding. IR spectra of the compounds including and not including hydrogen bonding were compared. The compounds 2 and 4 show the characteristic UV bands attributed to the NH-forms. According to the 1H-NMR spectral data the compound 2 has the strongest intramolecular hydrogen bonding and the compound 6 shows two isomeric structure. On the other hand, antibacterial and antifungal activities of the compounds were investigated. Most of the compounds show selective activity toward S. epidermidis and C. albicans. © 2011 Chemical Society of Ethiopia.