Akademik Veri Yönetim Sistemi
EUROPEAN GERIATRIC MEDICINE, cilt.4, ss.127, 2013 (SCI-Expanded, Scopus)
The relationship between leptin and obesity in postmenopausal osteoporosis A. Doventas, I.M. Bolayirli, S. Incir, H. Yavuzer, D.S. Erdincler, D. Konukoglu, T. Beger, A. Seven University of Istanbul, Cerrahpasa Medical School, Department of Internal Medicine, Division of Geriatrics, Istanbul, Turkey/University of Istanbul, Cerrahpasa Medical School, Department of Biochemistry, Istanbul, Turkey Background.– Obesity and bone metabolism are interrelated. The excessive secretion of leptin in obesity may either affect bone formation directly or indirectly affect bone resorption through upregulatedproinflammatorycytokineproduction.Theoveralleffects of leptinonbonemetabolismresultsfromabalancebetweennegative control, brain mediated effects and positive peripheral effects. The aim of this study is to investigate the relationship between obesity leptin/insulin resistance in postmenopausal osteoporosis. Material and methods.– Four study groups were included in the study. Group 1 (n=19): Osteoporosis (T Score<- 2.5 at the lumbar spine and/or femoral neck)+obese, group 2 (n=29): Nonosteoporosis+obese, group 3 (n=25): Osteoporosis+non-obese, group 4 (n=14): Non-osteoporosis+non-obese as control. The serum levels of leptin wwere measured by ELISA. Glucose and insulin levels were analyzed by colorimetric and electrochemiluminescence methods respectively. Results.– Comparisonofgroup1withgroup3revealedsignificantly higher(P<0.001)leptinlevelsintheformer.Leptinlevelsweresignificantly higher in group 1 compared to control group (P<0.05). Leptin levels were significantly higher in group 2 vs. control group (P<0.05). Conclusion.– Leptin levels are significant predictors in the development of osteoporosis and/or obesity in postmenopausal women. http://dx.doi.org/10.1016/j.eurger.2013.07.416