The role of adiponectin in atherosclerosis and thrombosis

Ekmekci H., Ekmekci Ö.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.12, sa.2, ss.163-168, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1177/107602960601200203
  • Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.163-168
  • Anahtar Kelimeler: adiponectin, atheroscierosis, thrombosis, ADIPOSE-SPECIFIC PROTEIN, PLASMA-PROTEIN, NITRIC-OXIDE, ADHESION MOLECULES, METABOLIC SYNDROME, GENE-EXPRESSION, OBESITY, DISEASE, APM1, FAT
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Obesity is a major risk factor for morbidity and mortality from cardiovascular causes. Adiponectin has been identified recently as one of the adipocytokines with important metabolic effects. it can suppress atherogenesis by inhibiting the adherence of monocytes, reducing their phagocytic activity, and suppressing the accumulation of modified lipoproteins in the vascular wall. In addition, as adiponectin decrease endothelial damage and stimulates production of NO from vascular endothelial cells, hypoadiponectinemia may be partially contribute to thrombus formation.