Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension

Karadeniz Y., Ozpamuk-Karadeniz F., Ahbab S., Ataoglu E., Can G.

MEDICINA-LITHUANIA, cilt.57, sa.12, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3390/medicina57121297
  • Dergi Adı: MEDICINA-LITHUANIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: vitamin D, blood pressure, hypertension, parathyroid hormone, RENIN-ANGIOTENSIN SYSTEM, NEGATIVE ENDOCRINE REGULATOR, SERUM 25-HYDROXYVITAMIN D, PARATHYROID-HORMONE, D LEVEL, ASSOCIATION, PREHYPERTENSION, DYSFUNCTION, THERAPY, DISEASE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background and objectives: Hypertension is a global health problem and a major risk factor for cardiovascular diseases. Vitamin D deficiency is closely related to high blood pressure and the development of hypertension. This study investigated the relationship between the vitamin D and blood pressure status in healthy adults, and their 8-year follow-up was added. Materials and Methods: A total of 491 healthy middle-aged participants without any chronic illness, ages 21 to 67 at baseline, were divided into two groups as non-optimal blood pressure (NOBP) and optimal blood pressure (OBP). NOBP group was divided into two subgroups: normal (NBP) and high normal blood pressure (HNBP). Serum 25-hydroxy vitamin D levels were measured with the immunoassay method. 8-year follow-up of the participants was added. Results: The average vitamin D level was detected 32.53 +/- 31.50 nmol/L in the OBP group and 24.41 +/- 14.40 nmol/L in the NOBP group, and a statistically significant difference was found (p < 0.001). In the subgroup analysis, the mean vitamin D level was detected as 24.69 +/- 13.74 and 24.28 +/- 14.74 nmol/L in NBP and HNBP, respectively. Together with parathyroid hormone, other metabolic parameters were found to be significantly higher in the NOBP. During a median follow-up of 8 years, higher hypertension development rates were seen in NOBP group (p < 0.001). Conclusions: The low levels of vitamin D were significantly associated with NBP and HNBP. The low levels of vitamin D were also associated with the development of hypertension in an 8-year follow-up.