Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Metastatic Urothelial Carcinoma Patients Treated With First-line Chemotherapy: A Large Multicenter Study

Auvray, Marie; Elaidi, Reza; Ozguroglu, MUSTAFA; Guven, Sermin; Gauthier, Helene; Culine, Stephane; Caty, Armelle; Dujardin, Charlotte; Auclin, Edouard; Thibaut, Constance; Combe, Pierre; Tartour, Eric; Oudard, Stephane

doi:10.1016/j.clgc.2016.10.013

Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Metastatic Urothelial Carcinoma Patients Treated With First-line Chemotherapy: A Large Multicenter Study

Auvray M., Elaidi R., Ozguroglu M., Guven S., Gauthier H., Culine S., ...Daha Fazla

CLINICAL GENITOURINARY CANCER, cilt.15, sa.3, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 3
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.clgc.2016.10.013
Dergi Adı: CLINICAL GENITOURINARY CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Biomarker, Inflammation, Overall survival, Prognostic value, Progression-free survival, TRANSITIONAL-CELL CARCINOMA, GEMCITABINE PLUS CISPLATIN, LONG-TERM-SURVIVAL, PRETREATMENT NEUTROPHIL, PREDICTING SURVIVAL, RADICAL CYSTECTOMY, BLADDER-CANCER, INFLAMMATION, CARBOPLATIN, OUTCOMES
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

This multicenter study assessed the prognostic value of the neutrophile-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation, for overall survival (OS) and progression-free survival (PFS) after first-line chemotherapy (CT) in 280 metastatic urothelial cancer patients. High pre-CT NLR was an independent predictor of reduced of OS (hazard ratio=1.36; P<.0001), highlighting the importance of an inflammatory cancer-related microenvironment.