The Effect of Vitamin U on Pentylenetetrazole Induced Epilepsy in Rats

Creative Commons License

Bayrak G., Yanardağ R.

IV International Eurasian Agriculture and Natural Sciences Congress, Konya, Türkiye, 30 - 31 Ekim 2020, ss.142, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Konya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.142
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet


THE EFFECT OF VITAMIN U ON PENTYLENETETRAZOLE INDUCED EPILEPSY IN RATS

Gamze Bayrak,Refiye Yanardag


Epilepsy is a serious brain disorder and affects many people all around the world. Pentylenetetrazole (PTZ) is a

selective GABAA antagonist and used for kindling epilepsy model. It causes elevation of oxidative stress and harms

brain and other organs. Vitamin U (Vit U) is a sulphur-containing substance and has antioxidant effect. In this study,

we aimed to investigate protective role of Vit U against PTZ-induced epilepsy model. Male Sprague-Dawley rats were

divided four groups as follows: Group I, saline given control group (for 7 days and intraperitoneally); Group II, Vit U

administered group (50 mg/kg/day; for 7 days and gavage); Group III, PTZ injected group (60 mg/kg, single dose,

intraperitoneally); Group IV, PTZ + Vit U group (in same dose and time). At the end of the experiment, brain tissues

were taken. They were homogenized. The glutathione, lipid peroxidation levels, alkaline phosphatase,

myeloperoxidase, xanthine oxidase, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase

activities were increased in PTZ group. Administration of Vit U reversed these results. In conclusion, we can say that

Vit U used its antioxidant property and protected brain tissue against PTZ sourced ROS.

Anahtar Kelimeler:Vitamin U, epilepsy,pentylenetetrazole