Calcium, magnesium, and zinc status in experimental hypothyroidism

ŞİMŞEK G., Andican G., Karakoc Y., Yigit G., Hatemi H., Candan G.

BIOLOGICAL TRACE ELEMENT RESEARCH, sa.3, ss.205-213, 1997 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1007/bf02784440
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.205-213
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

In this study, experimental hypothyroidism was established and used to investigate possible alterations in the calcium, magnesium, and zinc homeostasis by assessing their concentration in plasma and erythrocytes. Hypothyroidism was induced by administration of methimazole an iodine blocker at a dose of 75 mg/100 g food for 3 wk. In the methimazole-induced hypothyroid state, the experimental animals showed a significant decrease in plasma zinc concentration, whereas a significant increase in plasma magnesium concentration occurred. No change was observed in plasma calcium concentration. The erythrocyte zinc and calcium concentrations were found to be increased, whereas magnesium concentration decreased. Erythrocyte magnesium concentration showed a significant positive correlation with T-4 values. The study provides evidence for marked alterations in homeostatis of zinc, magnesium, and calcium.