Evaluation of Vancomycin-Resistant Enterococcus Isolates in Pediatric Clinic: An Experience From ATeaching and Research Hospital

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Aygun S. T., Aygun E., Arabaci C., Karbuz A.

JOURNAL OF PEDIATRIC INFECTION, cilt.19, sa.4, ss.246-255, 2025 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2025
  • Doi Numarası: 10.5578/ced.20250422
  • Dergi Adı: JOURNAL OF PEDIATRIC INFECTION
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.246-255
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: Infections due to vancomycin-resistant enterococci (VRE) have recently raised concern as an important ailment especially amongst children. This study aimed to evaluate the clinical characteristics and risk factors of cases with VRE isolation in our hospital > s pediatric clinic. Material and Methods: We retrospectively analyzed patients under 18 years of age with VRE isolation in our hospital's pediatric clinic between January 2014 and June 2022. Patients' demographic characteristics, admission diagnoses, risk factors, antibiotic use history, clinical courses, and laboratory findings were evaluated. Results: Of the 103 patients included in the study, 54.4% were male, with a mean age of 14.29 +/- 34.41 months. Of the patients, 61.2% were treated in the pediatric intensive care unit, while 20.4% were in the neonatal intensive care unit. The most common admission diagnoses were respiratory failure (30.2%), sepsis (13.0%), and congenital heart disease (9.5%). Among the risk factors, total parenteral nutrition (27.2%), catheter presence (22.3%), and tracheostomy (10.7%) were prominent. Of the patients, 86.4% had a history of antibiotic use during hospitalization. Of the isolated strains, 97.1% were identified as Enterococcus faecium. Of the isolates, 95.15% were evaluated as colonization and 4.85% as infection. Mortality rate was determined to be 8.8%. Conclusion: VRE colonization is more frequently observed in intensive care patients and those with prolonged hospitalization. The classification of risk factors followed by the proper infection control measures is important in the prevention of hospital acquired infections which are VRE associated.