SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus

Caliskan Z., Mutlu T., Guven M., Tuncdemir M., Niyazioglu M., Hacioglu Y., ...Daha Fazla

GENE, cilt.642, ss.542-548, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 642
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.gene.2017.11.071
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.542-548
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Sirtuins (SIRTs) is a family of NAD+ dependent histone deacetylases. SIRT6 takes play in glucose homeostasis, genomic stability and DNA repair. Although increased oxidative DNA damage and decreased DNA repair activity were determined in diabetes mellitus, the possible relation between level of oxidative DNA damage and SIRT6 expression has not been investigated so far. We determined SIRT6 expression and urinary 8-hydroxy deoxyguanosine (8-OHdG) levels, marker of oxidative DNA damage, in cases with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM).