Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood

KÜÇÜKSEZER, Umut; Palomares, Oscar; Rueckert, Beate; Jartti, Tuomas; Puhakka, Tuomo; Nandy, Andreas; Gemicioglu, BİLUN; Fahrner, Heinz; Jung, Andreas; Deniz, Gunnur; Akdiş, Cezmi; Akdis, Muebeccel

doi:10.1016/j.jaci.2012.10.051

Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood

KÜÇÜKSEZER U. C., Palomares O., Rueckert B., Jartti T., Puhakka T., Nandy A., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.131, sa.3, ss.875-894, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 131 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.jaci.2012.10.051
Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.875-894
Anahtar Kelimeler: Peripheral tolerance, tonsils, proinflammatory cytokines, IL-1 beta, IL-6, Toll-like receptors, allergen-specific T cells, myeloid dendritic cells, DENDRITIC CELLS, REGULATORY CELLS, IMMUNITY, INNATE, IMMUNOTHERAPY, CROSSTALK, RESPONSES, SUPPRESSION, INDIVIDUALS, MECHANISMS
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: The generation and maintenance of allergen-specific T-cell tolerance is a key step in healthy immune responses to allergens and successful allergen-specific immunotherapy. Breaking of peripheral T-cell tolerance to allergens can lead to the development of allergies, but the mechanisms are not completely understood.