Association between interleukin-1 beta (IL-1 ss) gene polymorphism and outcome after head injury: an early report

Uzan M., Tanriverdi T., Baykara O., Kafadar A. M., Sanus G., Tureci E., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.147, sa.7, ss.715-720, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 147 Sayı: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s00701-005-0529-z
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.715-720
  • Anahtar Kelimeler: head injury, interleukin, interleukin-1 beta, outcome, polymorphism, AMYLOID PROTEIN DEPOSITION, TRAUMATIC BRAIN-INJURY, ALZHEIMERS-DISEASE, RECEPTOR ANTAGONIST, CEREBRAL-ISCHEMIA, NERVOUS-SYSTEM, PRECURSOR PROTEIN, TEMPORAL PROFILE, EXPRESSION, CYTOKINES
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background. Recent studies focusing on the genetic influences on outcome after head injury (HI) have suggested that different alleles of certain genes are associated with different outcomes. Interleukin-1 beta (IL-1 beta) gene, especially beta 2 polymorphism, is frequently observed in Alzheimer's disease, a remarkable degenerative state in which HI is among the known risk factors. Therefore, the aim of this paper was to search for the possible association between the outcome and IL-1 beta gene polymorphism in human HI.