Prognostic Significance of Tumor Budding in Invasive Ductal Carcinoma of the Breast with Neuroendocrine Differentiation

Erginoz E., Cavus G. H., Ozturk T., Ilvan S., KAYADİBİ Y., Ozdil A., ...Daha Fazla

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2025 (SCI-Expanded, Scopus)

Özet

Introduction Invasive ductal carcinoma (IDC) with neuroendocrine differentiation (NED) is a rare subgroup of breast cancer that is treated the same way as invasive ductal carcinoma-no special type (IDC-NST). In this study, we aimed to study the effects of tumor budding on clinicopathological outcomes and survival.Methods Fifty-seven patients previously diagnosed with breast cancer were included in this analysis. Patients were grouped into IDC-NST and IDC with NED using the neuroendocrine markers chromogranin A and synaptophysin. Histological features were re-evaluated by two different pathologists in terms of tumor budding characteristics.Results Patients diagnosed with IDC with NED tended to be older (62.9 +/- 15.4 vs 51.7 +/- 9.9; P = 0.02). Compared to IDC-NST, IDC with NED group tended to display type A and B mammographic breast composition (P = 0.018), have higher tumor budding (2.7 vs 2, P = 0.009), larger in diameter (3.9 +/- 2.3 cm vs 2.5 +/- 1.5 cm; P = 0.015), and show higher lymphatic invasion (P = 0.017), vascular invasion (P = 0.042), and perineural invasion (P = 0.045). However, no differences were found in the 5-year overall survival and disease-free survival between the two groups.Conclusion Compared to IDC-NST, IDC with NED exhibited higher levels of tumor budding, were typically larger, and displayed higher lymphatic invasion, vascular invasion, and perineural invasion.