Akademik Veri Yönetim Sistemi
Fabad Journal of Pharmaceutical Sciences, cilt.45, sa.3, ss.229-241, 2020 (Scopus, TRDizin)
Green tea is obtained from freshly harvested camellia sinensis (l.) Kuntze (Theaceae) leaves by drying them under hot air or steam without oxidation and fermentation. Nowadays, it is widely used in the form of tea (as an infusion) and extract (as a capsul or tablet) for reducing the risk of cardiovascular diseases and weight loss. Despite its potential health benefits, severe side hepatocellular effects have been reported especially after the long-term consumption of green tea in high doses. in this review, the risk of hepatotoxicity caused the consumption of green tea has been evaluated by examining the clinical cases in the literature. Most of patients consumed green tea infusion and extracts have been presented to the emergency department with complaints of jaundice, abdominal pain and fatigue; as a result of examinations, it has been observed that hepatocellular type liver damage usually occurs because of the high amount of green tea used for a long time. it has been reported that the consumption of green tea extract fasting and at once at high doses [800 mg epigallocatechin gallate (eGcG)/day] causes abnormal changes in liver enzyme levels earlier than when consumed in divided doses throughout the day with or after meals. The results showed that the hepatic side effects of green tea depend on its dosage, dosage form and usage conditions. in these studies, hepatotoxicity of green tea was attributed to the main polyphenol component, eGcG. According to the results, the consumption of green tea should be avoided fasting, for a long time (more than 2 months) and at high doses (over 3-4 cups/day). consumption of green tea in the form of beverages should be preferred in the form of infusions or extract-based beverages, since they are better tolerated than in high doses in solid form (as an extract). This review showed that cases of green tea hepatotoxicity had been reported in many countries and, for this reason, safety measures to prevent liver toxicity must be implemented by the healthcare systems.