COX-2 GENE VARIANTS IN BIPOLAR DISORDER-I

Özdemircan A., Daşdemir S., Küçükali C. İ., Bireller E. S., Ozturk H., Çakmakoğlu B.

PSYCHIATRIA DANUBINA, vol.27, no.4, pp.385-389, 2015 (SCI-Expanded, SSCI, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2015
  • Journal Name: PSYCHIATRIA DANUBINA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.385-389
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Background: Bipolar disorder-I (BD-I) is a complex illness, and multiple genes and environmental factors determine its pathogenesis. Several studies have ascertained that BD-I and inflammation are linked through shared genetic polymorphisms and gene expression, as well as altered cytokine levels. COX-2 gene polymorphisms affecting COX-2 levels may be associated with BD-I by altering the inflammatory response.