Dedifferentiated Liposarcoma of the Gastroesophageal Junction
TURKISH JOURNAL OF PATHOLOGY, cilt.34, sa.1, ss.104-107, 2018 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.5146/tjpath.2014.01297
- Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.104-107
- Anahtar Kelimeler: Gastrointestinal neoplasms, Gastroesophageal junction, Dedifferentiated liposarcoma, REAL-TIME PCR, GIANT LIPOSARCOMA, STOMACH, DIAGNOSIS, AMPLIFICATION, ESOPHAGUS, SUBTYPE, SARCOMA, MDM2
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction.