Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis

Ovadia, Caroline; Sajous, Jenna; Seed, Paul; Patel, Kajol; Williamson, Nicholas; Attilakos, George; Azzaroli, Francesco; Bacq, Yannick; Batsry, Linoy; Broom, Kelsey; Brun-Furrer, Romana; Bull, Laura; Chambers, Jenny; Cui, Yue; Ding, Min; Dixon, Peter; Estiu, Maria; Gardiner, Fergus; Geenes, Victoria; Grymowicz, Monika; Gunaydin, Berrin; Hague, William; Haslinger, Christian; Hu, Yayi; Indraccolo, Ugo; Juusela, Alexander; Kane, Stefan; Kebapcilar, Ayse; KEBAPCILAR, LEVENT; Kohari, Katherine; Kondrackiene, Jurate; Koster, Maria; Lee, Richard; Liu, Xiaohua; Locatelli, Anna; Macias, Rocio; Madazli, RIZA; Majewska, Agata; Maksym, Kasia; Marathe, Jessica; Morton, Adam; Oudijk, Martijn; Oztekin, Deniz; Peek, Michael; Shennan, Andrew; Tribe, Rachel; Tripodi, Valeria; Ozterlemez, Naciye; Vasavan, Tharni; Wong, L.; Yinon, Yoav; Zhang, Qianwen; Zloto, Keren; Marschall, Hanns-Ulrich; Thornton, Jim; Chappell, Lucy; Williamson, Catherine

doi:10.1016/s2468-1253(21)00074-1

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis

Ovadia C., Sajous J., Seed P. T., Patel K., Williamson N. J., Attilakos G., ...Daha Fazla

LANCET GASTROENTEROLOGY & HEPATOLOGY, cilt.6, sa.7, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 6 Sayı: 7
Basım Tarihi: 2021
Doi Numarası: 10.1016/s2468-1253(21)00074-1
Dergi Adı: LANCET GASTROENTEROLOGY & HEPATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth, preterm birth, and neonatal unit admission). We aimed to examine whether ursodeoxycholic acid affects specific adverse perinatal outcomes.