A case of familial hypercholesterolemia that necessitated coronary bypass surgery in childhood

Yalcin Y., Bilal M. S., Zeybek C., Zeybek C. A., Celebi A.

TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS, cilt.41, sa.1, ss.51-54, 2006 (ESCI, Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 1
  • Basım Tarihi: 2006
  • Dergi Adı: TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.51-54
  • Anahtar Kelimeler: hypercholesterolemia, atherosclerosis, coronary by-pass, child
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Familial hypercholesterolemia is an autosomal dominant dyslipidemia, causing premature coronary artery disease. A 12-year-old girl with complaints of chest pain and syncope during the last six months was referred for cardiac evaluation. Echocardiographic examination revealed a hyperechogenic crescentic mass in the ascending aorta (wich was thought to be an atheroma) just above the aortic valve narrowing both coronary ostia. Coronary angiography showed 40% stenosis in the left main coronary artery, 80% stenosis in the left anterior descending artery, 95% stenosis in the ostium of the right coronary artery and 50% stenosis in the proximal part of the circumflex artery. She underwent a coronary artery by-pass grafting operation. The risk of premature coronary artery disease is high in familial hypercholesterolemia. Therefore, coronary angiography is useful in those patients who have ischemic symptoms.