Involvement of prostaglandin F-2 alpha in preeclamptic human umbilical vein vasospasm: a role of prostaglandin F and thromboxane A(2) receptors

Topal G., Foudi N., Uydes-Dogan B. S., Cachina T., Kucur M., Gezer A., ...Daha Fazla

JOURNAL OF HYPERTENSION, cilt.28, sa.12, ss.2438-2445, 2010 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 12
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/hjh.0b013e32833e868f
  • Dergi Adı: JOURNAL OF HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2438-2445
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective Preeclampsia is characterized by hypertension and proteinuria developing after 20 weeks of gestation. Increased vasoconstriction can be one of the major underlying pathophysiological event in this syndrome. We examined the role of vasoconstrictor prostanoid, prostaglandin F-2 alpha (PGF(2 alpha)) in preeclamptic and normotensive human umbilical veins.