Aortic elastic properties and circulating matrix biomarkers in children with bicuspid aortic valve: an exploratory study
PEDIATRIC RESEARCH, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1038/s41390-026-05261-4
- Dergi Adı: PEDIATRIC RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE, Health Research Premium Collection (ProQuest)
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
BACKGROUND: Bicuspid aortic valve (BAV) is associated with early aortopathy that may precede overt aortic dilatation. Functional assessment of aortic biomechanics and extracellular matrix (ECM) biomarkers may provide additional insight beyond conventional diameter-based evaluation. METHODS: In this prospective case-control study, 40 children with BAV and 40 healthy controls underwent echocardiographic assessment of ascending aortic elastic properties and left ventricular global longitudinal strain (GLS). ECM-related biomarkers were measured using ELISA. RESULTS: Children with BAV demonstrated significantly impaired aortic elastic properties, including lower aortic strain (14.79 +/- 2.41 vs 21.03 +/- 2.94) and distensibility (2.3 [2.0-3.15] vs 4.7 [4.1-5.7] & times;10-3 mmHg-1, p < 0.001) and higher aortic stiffness index despite preserved GLS (p > 0.05). Ascending aortic Z-scores were significantly higher in the BAV group. Serum MMP-2, MMP-9, and MMP-2/ TIMP-1 ratio levels were elevated in children with BAV and were associated with impaired aortic elastic parameters. TGF-beta 1 levels did not differ between groups but demonstrated modest correlations with aortic biomechanics within the BAV cohort. CONCLUSION: In children with BAV, impaired aortic biomechanics and ECM remodeling appear to precede before overt myocardial dysfunction. Integrated functional imaging and biomarker assessment may enhance detection of BAV-related aortopathy.