Effects of hormone replacement therapy on lipid peroxides and oxidation system in postmenopausal women
Journal of Toxicology and Environmental Health - Part A, cilt.59, sa.1, ss.1-5, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 1
- Basım Tarihi: 2000
- Doi Numarası: 10.1080/009841000157023
- Dergi Adı: Journal of Toxicology and Environmental Health - Part A
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1-5
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
A short-term evaluation of 6 months of estrogen therapy on oxidant status in 38 postmenopausal women was conducted. The levels of serum lipid peroxidation products, glutathione (GSH) status, and glutathione-related enzymes were evaluated before and after 6 months of hormone replacement therapy. After 6 months of estrogen treatment there was a significantly increased concentration of thiobarbituric acid-reactive substances (TBARS), which are an end product of lipid peroxidation. This was accompanied by a significant increase in the activity of glutathione peroxidase (GSH-Px). However, the activities of glutathione reductase (GSSG-R) and superoxide dism utase (SOD) were significantly decreased and total protein thiols were reduced. Data suggest that hormone replacement therapy in postmenopausal women is associated with oxidant mechanisms. © 2000 Taylor & Francis Group, LLC.