Voriconazole Induced Bradycardia

Uludag D., Ozdemir N., Tuysuz G., Eroglu A. G., Celkan T.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.30, sa.7, ss.674-676, 2013 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/08880018.2013.775616
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.674-676
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Voriconazole is a triazole antifungal drug that is used to treat invasive fungal infections, especially aspergillus. Here, we report two children who had severe bradycardia associated with voriconazole at a dose of 12 mg/kg per day. Bradycardia resolved in 24 hours in both after decreasing the dose to 10 mg/kg per day. Heart rates were in normal limits on follow-up. Bradycardia may be a side effect of voriconazole treatment in children under immunosuppressive treatment. Heart rate should be monitored in patients receiving voriconazole and other triazole treatments.