Akademik Veri Yönetim Sistemi
8 th International Conference on New Trends in Chemistry, Gazimagusa, Kıbrıs (Kktc), 16 - 18 Mayıs 2022, ss.53, (Özet Bildiri)
Heterocyclic quinones with at least one heteroatom such as nitrogen [1] are an exceptionally
important class of compounds [2]. Quinolinequinone (azanapthoquinone) is a class of
nitrogen-containing bicyclic heterocyclic compounds that are of great importance and form
the crucial core in a variety of drugs, many natural products, and pharmaceutically active
compounds including anticancer, antibacterial, antimalarial, anti-HIV, antiviral, antichagasic,
and antifungal agents [3].
Despite significant progress in research on heterocyclic quinone chemistry, considerable
efforts continue to be made to identify new quinolinequinone compounds with strong
bioactivity. A preliminary assessment of the structure-activity relationship (SAR) from our
previous studies suggests that the replacement of the phenyl ring by the methyl groups (to
form plastoquinone analogues) is essential for the biological activities [4]. In this study, the
relationship between the bioactivity of quinones and the number and position of heteroatoms
in heterocyclic quinones has been extensively studied.