Akademik Veri Yönetim Sistemi
6th International Congress on Advances in Bioscience and Biotechnology (ICABB), Aksaray, Türkiye, 25 - 29 Temmuz 2022, ss.35-43, (Tam Metin Bildiri)
Mammary tumors are pathological cases that originate from the mammary gland and canine mammary
tumors have an important role in in the treatment of human mammary tumors due to the similarities with
human mammary tumors. Tannic acid (TA) has drawn attention due to its anticancer properties specifically
inducing apoptosis in some types of cancers. In the veterinary field, there is no study yet on the effectiveness
of TA in canine mammary tumors. For this purpose, we aimed to evaluate the apoptotic effect of TA on
canine mammary carcinosarcoma (CMCS) cells which were obtained from an 11-year-old female with the
complaint of a mass (3-5 cm). We determined the potential therapeutic effect of TA on CMCS cells through
the viability WST-1 assay, Annexin-V analysis and Acridine Orange (AO) staining. Our findings
demonstrated that TA significantly inhibited cell viability and caused apoptotic cell death with
characteristic apoptotic morphology. Therefore, our results suggest that TA-based therapy could be a
promising strategy for the treatment of CMCS cells. However, more studies are needed to elucidate the
therapeutic effects of TA on different subtypes of canine mammary tumors with advanced molecular
analysis.