Development of self-healing vanillin/PEI hydrogels for tissue engineering

Yasar M., OKTAY B., Dal Yontem F., Aldogan E., KAYAMAN APOHAN N.

EUROPEAN POLYMER JOURNAL, cilt.188, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 188
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.eurpolymj.2023.111933
  • Dergi Adı: EUROPEAN POLYMER JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Self-healing materials recover mechanical damages to expand the lifetime of the material provided. In this study, self-healing hydrogels have been successfully prepared using a novel and simple technique. Vanillin is a natural monomer, used as a bio-based cross-linker for UV-induced bonding and Schiff-base bonding. Methacrylate-functionalized vanillin (M-VAN) is covalently integrated with the polymer matrix. While M-VAN supports polymer matrix with its vinyl group, its aldehyde functionality helps the formation of dynamic covalent imine bonds via Schiff-base formation. The hydrogel showed excellent self-healing ability overnight under physio-logical conditions without external addition. In addition, the hydrogel surface was modified by collagen and its cell viability was investigated. The prepared scaffolds showed good cell viability of 124% and 163% compared to the control sample. The developed self-healing material reveals that it has possible uses for future biomedical applications and tissue engineering studies due to the self-healing mechanism taking place under ambient conditions.