Metal–organic frameworks (MOFs) in drug Delivery: Emerging trends, functional enhancements, and biocompatibility challenges

Filiz, Alper; BAYAZİT, ŞAHİKA; BARLAS, FIRAT

doi:10.1016/j.jddst.2025.107284

Metal–organic frameworks (MOFs) in drug Delivery: Emerging trends, functional enhancements, and biocompatibility challenges

Filiz A., BAYAZİT Ş. S., BARLAS F. B.

Journal of Drug Delivery Science and Technology, cilt.112, 2025 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 112
Basım Tarihi: 2025
Doi Numarası: 10.1016/j.jddst.2025.107284
Dergi Adı: Journal of Drug Delivery Science and Technology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Metal–organic frameworks (MOFs) exhibit remarkable design versatility, precise pore architectures, responsiveness to external stimuli, high surface area, and adjustable morphology. This review presents a comprehensive summary of MOF-based nanocarriers for drug delivery developed over the past decades, emphasizing essential structural features. We also examine various modifications that can enhance or redirect MOF functionality to improve targeting efficiency or reduce off-target effects. Overall, this review offers researchers valuable insights into recent progress and ongoing challenges in the field of MOF-based drug delivery systems.