Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease

Agirbasli, M.; GÜNEY, AHMET; Ozturhan, H.; Agirbasli, DENİZ; ULUCAN, KORKUT; Sevinc, D.; Kirac, D.; Ryckman, K.; Williams, S.

doi:10.1177/1741826711398806

Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease

Agirbasli M., GÜNEY A. İ., Ozturhan H. S., Agirbasli D., ULUCAN K., Sevinc D., ...More

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, vol.18, no.6, pp.803-809, 2011 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 18 Issue: 6
Publication Date: 2011
Doi Number: 10.1177/1741826711398806
Journal Name: EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.803-809
Keywords: ACE I/D, coronary artery disease, eNOS 3-27, Gln192Arg PON1, MTHFR C677T, multifactor dimensionality reduction, PAI-1 4G/5G, EPISTASIS
Istanbul University-Cerrahpasa Affiliated: No

Abstract

Background: Association studies in the Turkish population have investigated the single locus effects of different gene polymorphisms on coronary artery disease (CAD). CAD is a complex polygenic disease that involves complex interactions among multiple genetic and environmental conditions.