Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease

Agirbasli, M.; GÜNEY, AHMET; Ozturhan, H.; Agirbasli, DENİZ; ULUCAN, KORKUT; Sevinc, D.; Kirac, D.; Ryckman, K.; Williams, S.

doi:10.1177/1741826711398806

Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease

Agirbasli M., GÜNEY A. İ., Ozturhan H. S., Agirbasli D., ULUCAN K., Sevinc D., ...Daha Fazla

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, cilt.18, sa.6, ss.803-809, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 6
Basım Tarihi: 2011
Doi Numarası: 10.1177/1741826711398806
Dergi Adı: EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.803-809
Anahtar Kelimeler: ACE I/D, coronary artery disease, eNOS 3-27, Gln192Arg PON1, MTHFR C677T, multifactor dimensionality reduction, PAI-1 4G/5G, EPISTASIS
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Background: Association studies in the Turkish population have investigated the single locus effects of different gene polymorphisms on coronary artery disease (CAD). CAD is a complex polygenic disease that involves complex interactions among multiple genetic and environmental conditions.