Akademik Veri Yönetim Sistemi
FEBS EMBO 2014 Conference, Paris, Fransa, 30 Ağustos - 04 Eylül 2014, cilt.281, ss.535-536, (Özet Bildiri)
Preeclampsia and pregnancy loss are considered to result from under perfusion of placenta due to structural and occlusive changes including thrombosis in the placental vessels. The effects of adipocytokines on endothelial function, inflammation and adipocyte metabolism makes them key players in the pathogenesis of metabolic syndrome, a cluster of clinical symptoms including obesity, insulin resistance, hypertension-related diseases. In addition, the anti-angiogenic state in preeclampsia may partially affect of platelet function via changed levels of nitric oxide and prostacyclin. In this study, some of the adipocytokines, angiogenesis-related factors and platelet aggregation levels were determined and correlated in patients with preeclampsia and control pregnant womens. 52 preeclamptic and 27 control pregnant women were included into the scope of this study. Ghrelin, leptin, adiponectin, transforming growth factor b1 (TGFb1), von willebrand factor (vWF), vascular endothelial growth factor (VEGF), endoglin, placental growth factor (PlGF) and P-selectin levels were determined by ELISA. Colorimetric method was used to determine the nitric oxide levels. Platelet aggregation tests with adenosine diphosphate (ADP) were analyzed by using aggregometer. In patients with preeclampsia, blood leptin, vWF and endoglin levels were found to be significantly higher than controls (p < 0.001) Contraversely, blood PIGF levels was lower in pre-eclamptic patients than controls (p < 0.001). In addition; we could not found any significant difference for ghrelin, adiponectin, TGF b1, VEGF, nitric oxide, P-selectin and ADP-induced platelet aggregation levels between preeclamptic and control pregnant womens. According to pearson correlation test, there was positive correlations between endoglin and vWF, endoglin and leptin [ rp = 0.322, p = 0.005; rp = 0.420, p = 0.000, respectively], and negative correlations between PlGF and vWF, PlGF and Endoglin, PlGF and leptin [ rp = 0.507, p = 0.000; rp = 0.388, p = 0.000; rp = 0.381, p = 0.000, respectively] This study demonstrated that altered blood levels of the angio-genesis-related factors were not related with platelet aggregation in preeclamptic patients. Although insignificant positive correlations, increased leptin and vWF levels may still contribute to platelet activation/aggregation in patients with severe preeclampsia.