Enfeksiyöz Ajanlarla Mücadelede Yenilikçi Bir Molekül: Skualamin

Antibiotic resistance, which is a major threat for human and animal health, is becoming a bigger problem every day by making treatment difficult and new ways of solution are sought for it. It has been reported that long-term intravenous use of colistin and aminoglycosides from agents developed against multi-drug resistant bacteria causes many toxic effects in many organs, especially in kidney. In this context, there has been an increase in interest in the antimicrobial efficacy of aminosterol derivatives, which are innovative molecules in recent years. Squalamine is a natural aminosterol, which was discovered and isolated firstly in the tissues of the dogfish shark (Squalus acanthias) in 1993 and later within the circulating white blood cells of the sea lamprey (Petromyzon marinus), that is a parasitic fish, in 2007. It is an innovative molecule has many therapeutic efficiency including antimicrobial and antiangiogenic features which has been previously demonstrated with in vivo and in vivo reviews. Squalamine’s effect on infectious agents is explained by the changes in the cell membrane of microorganisms. İt is aimed to give detailed information about squalamine, which we believe to be a new treatment option for veterinary medicine to combat infectious agents.