Prenatal expressions of hyperpolarization-activated cyclic-nucleotide-gated channel (HCN) genes in dysplastic hippocampi in rats.
Turkish neurosurgery, cilt.18, sa.4, ss.327-35, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 4
- Basım Tarihi: 2008
- Dergi Adı: Turkish neurosurgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.327-35
- Anahtar Kelimeler: Dysplasia, HCN1, HCN2, Gene expression, Hippocampal sclerosis, Temporal lobe epilepsy, H-CHANNELS, PACEMAKER CHANNELS, FEBRILE SEIZURES, I-H, ABSENCE EPILEPSY, EXCITABILITY, MECHANISMS, NETWORK, MODEL
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
AIM: Hyperpolarization-activated cyclic nucleotide-gated (HCN or h-channel) channels mediate hyperpolarization-activating currents in the hippocampus and neocortex. The aim of this study is to present prenatal h-channel gene expressions (HCN1 and HCN2; HCN1-Entrez-Gene ID: 84390; HCN2- Entrez Gene ID: 114244) in dysplastic hippocampal pyramidal neurons induced by in utero irradiation in rats.