Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The Istanbul Perspective


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Karakas Z., Koc B., Temurhan S., Elgun T., Karaman S., Asker G., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.32, no.4, pp.344-350, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.4274/tjh.2014.0204
  • Title of Journal : TURKISH JOURNAL OF HEMATOLOGY
  • Page Numbers: pp.344-350

Abstract

Objective: Alpha thalassemia syndromes are caused by mutations on one or more of the four a-globin genes. Mutations could be either more commonly deletional or non-deletional. As some deletions (3.7 and 4.2) cause alpha(+)-thalassemia, some cause (-20.5, MED, THAI, FIL) alpha(0)-thalassemia. The aim of this study was to determine alpha thalassemia mutations in patients with unsolved hypochromic microcytic anemia and to evaluate types of mutations.