Research Information System
WCIM 2016 – The 33rd World Congress of Internal Medicine 22 - 25 August 2016, Denpasar, Indonesia, 22 - 25 August 2016, (Summary Text)
Backround: White coat hypertension (WHT) may lead to cardiovascular target
organ damage similar to sustained hypertension (HT). Endothelial dysfunction is
one of the earliest manifestations of atherosclerosis. Lectin-like oxidized low
density lipoprotein receptor-1 (LOX-1) was identified from endothelial cells as
the molecule that induces endothelial dysfunction triggered by oxidized lowdensity lipoprotein (oxLDL). LOX-1 is viewed as a mediator and biomarker of
endothelial or vascular dysfunction. Measurement of soluble LOX-1 (sLOX-1)
may provide a novel diagnostic tool for the evaluation and prediction of
endothelial dysfunction and vascular disease. We investigated the sLOX-1 levels
in patients with HT and WCH, the association of sLOX-1 with oxLDL,
endothelial nitric oxide synthase (eNOS) and carotid intima–media thickness
(CIMT) between HT, WCH patients and healthy controls. Methods: The three
groups, HT, WCH and controls, were comprised of 35 patients each. CIMT were
measured on ultrasonography images. oxLDL, sLOX-1, total nitic oxide (NOx)
levels and eNOS activity were measured from collected blood samples. All
statistical comparisons were performed using the analysis of variance was used to
compare multiple-group means. Results: oxLDL and sLOX-1 levels were
significantly higher in the HT and WCH groups than in the control group
(P<0.001, P=0.011; P<0.001,P=0.019 respectively). But sLOX-1 levels were
significantly higher in the HT group compared with the WCH group. eNOS levels
were significantly lower in the HT group than in the control group. There were no
significant differences between the WCH and control group. CIMT measurements
were significantly higher in the WCH and HT groups compared with control
(p<0.001). There was a significant positive correlation between CIMT and sLOX1. Conclusion: A possible endothelial impairment may act as a cardiovascular
risk factor in WCH. We believe sLOX-1 level is strong biomarker for determining
early endothelial damage in HT, and especially in WCH patients.