Serum endocan concentration in women with pre-eclampsia

Yuksel M. A., Tuten A., Oncul M., Acikgoz A. S., YUKSEL I. T., Toprak M. S., ...Daha Fazla

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, sa.1, ss.69-73, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00404-014-3605-x
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-73
  • Anahtar Kelimeler: Endocan, Pre-eclampsia, Inflammation, CELL-SPECIFIC MOLECULE-1, VEGF-A, PATHOGENESIS, ESM-1, DIAGNOSIS, BIOMARKER, MARKER, TARGET
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Purpose To investigate serum endocan levels in pregnant subjects with and without pre-eclampsia. Methods This cross-sectional study was conducted on 49 pregnant women with pre-eclampsia and 32 healthy pregnant women matched for gestational age. Maternal levels of serum endocan were measured with the use of an enzyme-linked immunosorbent assay kit. Results Mean endocan levels were not significantly different among groups (10.7 +/- 4.5 vs. 10.3 +/- 3.2 ng/mL, p 0.763). Mean uterine artery PI and RI were higher in the pre-eclampsia group (p < 0.001, p < 0.001). Mean endocan levels were negatively correlated with BMI at the time of blood sampling (r = -0.247, p = 0.044). There was no correlations between mean endocan levels and all the others parameters. Conclusion These findings suggest that the role of endocan in the pathogenesis of pre-eclampsia was not related to pre-eclampsia; hence, further studies are needed to investigate the role of endocan in the pathogenesis of preeclampsia.