Protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss

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Edizer D. T., Yigit O., Cinar Z., GÜL M., Kara E., Yigitcan B., ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.97, pp.83-88, 2017 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 97
• Publication Date: 2017
• Doi Number: 10.1016/j.ijporl.2017.03.034
• Journal Name: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.83-88
• Keywords: Nigella sativa, Gentamicin, Hearing loss, Intratympanic, AMINOGLYCOSIDE-INDUCED OTOTOXICITY, CISPLATIN-INDUCED NEPHROTOXICITY, INDUCED HAIR CELL, GUINEA-PIGS, ANIMAL-MODEL, RATS, PREVENTION, THYMOQUINONE, INHIBITOR, TOXICITY
• Istanbul University-Cerrahpasa Affiliated: No

Abstract

Objective: Aminoglycosides, used to combat with life-threatening infections, have a substantial risk of hearing loss. Nigella sativa is an annual herbaceous plant and used for treatment of many diseases for ages. We aimed to investigate the protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss in an animal model.