SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL PROPERTIES OF NOVEL PIPERIDINOLYL-, PIPERIDINYL-, AND PIPERAZINYL-SUBSTITUTED NAPHTHOQUINONE COMPOUNDS AND THEIR REACTIONS WITH SOME THIOLS

Ibis C., Ayla S., Bahar H., Stasevych M. V., Komarovska-Porokhnyavets O., Novikov V.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.190, no.9, pp.1422-1433, 2015 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 190 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.1080/10426507.2014.986268
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1422-1433
  • Keywords: 2,3-dichloro-1, 4-naphthoquinone, piperidinole, piperazine, piperidine, pubstitution, 1,4-NAPHTHOQUINONE, ANTIBACTERIAL, DERIVATIVES
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Nucleophillic substitution reactions of 2,3-dichloro-1,4-naphthoquinone (1) were studied using a variety of piperidinol, piperidine, and piperazine derivatives. The N-substituted compounds were treated with some thiols and N,S-substituted compounds were formed. The structures of the new products were characterized by spectroscopic methods (H-1 NMR, C-13 NMR, MS) and elemental analysis. The novel compounds were evaluated for their antibacterial and antifungal activity.