Reversal of Rocuronium-Induced Neuromuscular Blockade by Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children
Eurasian Journal of Medicine, vol.55, no.3, pp.173-177, 2023 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 55 Issue: 3
- Publication Date: 2023
- Doi Number: 10.5152/eurasianjmed.2022.22090
- Journal Name: Eurasian Journal of Medicine
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.173-177
- Keywords: desflurane, Pediatric anesthesiology, rocuronium, sevoflurane, sugammadex
- Istanbul University-Cerrahpasa Affiliated: Yes
Abstract
Objective: In children, neuromuscular blockers may have different effects with various inhalation agents and incomplete reversal of the blockade continues to be a problem. The aim of the study is to observe the effects of sugammadex on reversing the blockade by a single dose of rocuronium, the peak inspiratory pressure, hemodynamic parameters in children under sevoflurane and desflurane anesthesia. Materials and Methods: One hundred forty-eight children aged 2-10 years old, to be operated under short-term general anesthesia, were enrolled in this prospective randomized controlled trial. After induction, the patients were intubated at the end of TOF (Train-of-four) ratio of 1.0-0. The time taken until TOF reached 0.25 was recorded, and 2 mg/kg sugammadex was administered to the patients. The period until the TOF was at least 0.9 and in the first 10 minutes after sugammadex injection, peak inspiratory pressure, the sys-tolic-diastolic arterial pressure, and the heart rate were monitored and possible side effects were observed in the recovery room. Results: Following the injection of sugammadex, the time taken for TOF of 0.25 to reach >0.9 was significantly shorter in the 2-4-year-old age group under sevoflurane anesthesia. After sugammadex injection, a small but statistically significant increase in peak inspiratory pressure values was observed in Group D at the 2nd, 5th, and 10th minutes. Conclusion: Rapid and complete recovery was achieved from the block induced by a single dose of 0.6 mg/ kg rocuronium by the use of sugammadex which did not give rise to any side effects.