Maternal serum copeptin concentrations in early- and late-onset pre-eclampsia

Tuten A., Oncul M., Kucur M., Imamoglu M., Ekmekci Ö., Acikgoz A. S., ...Daha Fazla

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, sa.4, ss.350-354, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.tjog.2013.10.045
  • Dergi Adı: TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.350-354
  • Anahtar Kelimeler: copeptin, early-onset pre-eclampsia, gestational age, late-onset pre-eclampsia, pre-eclampsia, CORTICOSTEROID-BINDING GLOBULIN, CORTICOTROPIN-RELEASING-FACTOR, ARGININE-VASOPRESSIN, INSULIN-RESISTANCE, PREGNANCY, CORTISOL, PLASMA, SECRETION, RISK
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: Early-onset pre-eclampsia is primarily associated with placental dysfunction, whereas late-onset pre-eclampsia is defined as a maternal constitutional disorder. As a protein cosynthesized with vasopressin, copeptin is a potential marker of metabolic syndrome and insulin resistance, which shares similar risk factors with pre-eclampsia. The aim of this study was to investigate the copeptin levels in patients with early-onsa and late-onset pre-eclampsia. Materials and methods: A total of 80 pregnant women receiving antenatal and obstetric care were recruited. The patients were subdivided into four groups: Early-onset pre-eclampsia (n = 20), late-onset pre-eclampsia (n = 20), and two control groups of similar gestational ages for both pre-eclamptic groups (n = 20 in each group). The maternal serum copeptin levels were measured using an enzyme-linked immunosorbent assay. Results: The mean copeptin levels were 0.92 +/- 0.57 ng/mL and 1.65 +/- 0.95 ng/mL in the early-onset and late-onset pre-eclampsia groups, respectively. These values were higher compared with the control groups (0.54 +/- 0.25 ng/mL and 1.15 +/- 0.94 ng/mL, respectively). However, the difference was only statistically significant in the early-onset pre-eclampsia group (p = 0.011). Copeptin levels were associated only with gestational age and systolic diastolic blood pressure. Conclusion: Our results suggest that copeptin levels might be useful in the evaluation of the severity of pre-eclampsia. However, copeptin might be involved in early-rather than late-onset pre-eclampsia. Copyright (C) 2015, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.