Research Information System
Colloids and Surfaces B: Biointerfaces, vol.265, 2026 (SCI-Expanded, Scopus)
Antimicrobial peptides (AMPs) are notable therapeutic candidates with broad-spectrum activity, yet their clinical application remains limited by enzymatic degradation, poor bioavailability, and potential cytotoxicity. Although new AMPs continue to be discovered, delivery strategies remain fragmented, highlighting the need for a coherent overview to guide future research. This review examined 93 studies published between 2022 and 2025, covering 63 distinct AMPs, and categorized nanocarrier systems into four sections: hydrogels, vesicles, structures with inorganic core, and miscellaneous approaches. These carriers have been consistently shown to enhance stability, safety, and delivery efficiency, with additional benefits in combination therapies. Despite these advances, challenges remain in scalability, long-term safety, and regulatory approval. Nanocarrier systems show strong potential to advance AMPs toward clinical use, with further progress relying on improved design, testing, and delivery strategies.