Akademik Veri Yönetim Sistemi
19th Nanoscience and Nanotechnology Conference, Ankara, Türkiye, 27 - 29 Ağustos 2025, ss.200, (Özet Bildiri)
In this study, hydrogel-based wound dressings were developed to enable the transdermal delivery of ibuprofen, and their swelling capacity, mechanical
strength, and drug release profiles were optimized.
The hydrogels, which were examined for their drug release profiles, were synthesized using acrylamide (AAm) and N,N′-methylene bis(acrylamide)
(MBAA) monomers through crosslinking polymerization in an acidic aqueous medium [1-3]. To enhance the swelling capacity and reduce the proportion
of synthetic monomers, hyaluronic acid (HA) was incorporated into the structure. HA, with its high molecular weight, improved the swelling capacity by
increasing the distance between crosslinks and supported controlled drug release [4].
Subsequently, carbon quantum dots (CQDs) derived from Lawsonia inermis (henna) were incorporated into the hydrogel matrix. Due to their small size
and large surface area, CQDs enhanced skin permeability, enabling deeper penetration of drugs and ensuring controlled release. Microwave-assisted
methods were employed for environmentally friendly and cost-effective production. The structural and morphological properties of the produced hydrogels
were analyzed using FTIR, SEM, EDS, and UV-Vis spectroscopy techniques