HLA B-27 subtypes in turkish patients with spondyloarthropathy and healthy controls

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OGUZ F., OCAL L., DILER A., OZKUL H., Asicioglu F., KASAPOGLU E., ...Daha Fazla

DISEASE MARKERS, cilt.20, sa.6, ss.309-312, 2004 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1155/2004/565270
  • Dergi Adı: DISEASE MARKERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.309-312
  • Anahtar Kelimeler: spondyloarthropathy, HLA-B27, HLA-B27 POLYMORPHISM, SUSCEPTIBILITY, ANTIGEN
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA.