Poisoning by butylated hydroxytoluene quinone methide acting as a superwarfarin: first reported case in humans

Hindilerden F., Aksoy E., Oztuerkmen A. Y., Turker G., Gulturk E., HANÇER V. S., ...Daha Fazla

BLOOD COAGULATION & FIBRINOLYSIS, cilt.35, sa.5, ss.279-281, 2024 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 5
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1097/mbc.0000000000001307
  • Dergi Adı: BLOOD COAGULATION & FIBRINOLYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.279-281
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Superwarfarins are anticoagulant rodenticides nearly 100-fold potent than the parent compound. Since their development, accidental and intentional cases of superwarfarin poisoning have been reported. We report the first human case of poisoning by butylated hydroxytoluene (BHT) quinone methide acting as a superwarfarin otherwise reported to be a well tolerated food additive and preservative and used as an antioxidant, stabilizer, anti-skinning agent in various industries. We aim to highlight the possible underlying cause of this previously unreported and potentially lethal BHT-related complication in the human.