The role of lipid peroxidation and calcium in galactosamine induced toxicity in the rat liver

Seckin S., Kocak-Toker N., Uysal M., ÖZ A. B.

Research Communications in Chemical Pathology and Pharmacology, cilt.80, sa.1, ss.117-120, 1993 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 1
  • Basım Tarihi: 1993
  • Dergi Adı: Research Communications in Chemical Pathology and Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.117-120
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Liver homogenate and subcellular fractional levels of lipid peroxides, homogenate glutathione (GSH) and calcium contents and hepatic plasma membrane Ca2+-ATPase activity were determined in rats, 12, 18, 24 and 48 hours after treatment with a single dose of 1 g/kg galactosamine. Lipid peroxides and calcium levels in liver homogenate and subcellular fractions were found to increase, but hepatic GSH content and Ca2+-ATPase activity were observed to decrease reversibly.