Akademik Veri Yönetim Sistemi
A Closer Look at Neuroendocrine Carcinomas, Joav Merrick, Editör, NOVA Science Publishers, New York, ss.1-22, 2022
Neuroendocrine tumors of the breast are a special
type of cancer that accounts for 2-5% of all breast cancers. Studies in the
literature are mostly shared in the form of large case series or case reports.
For this reason, the effects of neuroendocrine features on prognosis and the
choice of treatment are still a matter of debate. In our clinic which included
1203 patients with malignant breast lesions detected between 2010-2021, those
with neuroendocrine features were detected in only 89 tumors. The 55 of 89
lesions whose data were accessed were evaluated in two groups as neuroendocrine
cancer of the breast (n = 11) and breast cancer with neuroendocrine features (n
= 44). In the study, 50 randomly selected ductal breast cancers without neuroendocrine
features were included as the control group. Demographic, histopathological,
and radiological features were recorded and compared statistically. In our
study, it was found that tumors with neuroendocrine features appeared in the
older (p < 0.001) population compared to the invasive ductal breast cancers
without neuroendocrine features (BC-WNE) group and showed less typical features
of malignant breast tumors such as irregular shape (p < 0.001), spiculation
(p < 0.001) and calcification (p = 0.001). In this part of the book, we
discussed how the neuroendocrine structure affects the histopathological,
clinical, and radiological features of breast cancer by comparing it with other
comprehensive studies in the literature.