Akademik Veri Yönetim Sistemi
Journal of Research in Pharmacy, cilt.30, sa.2, ss.703-732, 2026 (ESCI, Scopus, TRDizin)
Amino acids and vitamins play crucial roles in pharmaceutical applications, serving as excipients and structural components of drug delivery systems due to their biological diversity and functionality. In this study, to improve the efficiency of drug delivery systems, graphene oxide (GO) nanoplatelets were surface-modified using green chemistry principles with different amino acids (ornithine, proline, leucine, tryptophan, glutamic acid) and one vitamin (nicotinic acid—vitamin B3). The modification processes were conducted at 85°C, and the resulting adsorbent were characterized using DLS, FTIR, and SEM techniques. The drug adsorption capacities of the resulting novel adsorbents were investigated and compared with the adsorption capacity of unmodified GO. In the adsorption studies, fluoxetine hydrochloride (FLX), a selective serotonin reuptake inhibitor (SSRI), was chosen as the model drug, and batch adsorption experiments were performed at varying concentrations. The concentrations of fluoxetine hydrochloride were determined at 226 nm using UV–Visible spectrophotometry. According to the findings, GO nanoplatelets demonstrated a high FLX adsorption capacity of 157 mg/g. Materials modified with amino acids exhibited lower adsorption capacities than GO nanoplatelets. However, GO nanosheets modified with nicotinic acid (vitamin B3) showed excellent adsorption capacity (252 mg/g) compared to pristine GO, highlighting the effectiveness of the modification. This means the adsorption capacity of fluoxetine hydrochloride increased by approximately 60% compared to GO. These results indicate that surface modification of GO with amino acids and vitamins has a meaningful impact on drug adsorption performance. Moreover, study suggests that biomolecule-based modifications could be a promising approach in the design of graphene oxide-based drug delivery systems. This study is one of the first comprehensive studies using amino acids and vitamin B3 in the surface modification of graphene oxide (GO) nanoplatelets in drug delivery systems. Our study reported a significant increase in drug adsorption as a result of both adopting a green chemistry approach and functionalizing the GO surface with biomolecules not found in the literature.