Evaluation of the Sustained Damage in Brain and Heart Tissues of Rats Following Inhalation of Chlorine Gas and the Efficiency of N-acetylcysteine
ERCIYES MEDICAL JOURNAL, cilt.31, sa.4, ss.293-298, 2009 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 4
- Basım Tarihi: 2009
- Dergi Adı: ERCIYES MEDICAL JOURNAL
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.293-298
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Purpose: Determination of the sustained damage in brain and heart tissues of rats due to exposure to chlorine gas inhalation and investigation of the role of N-acetylcysteine over that damage. Material and Methods: A total of 50 rats were split into 5 groups all of which contained 10 rats. No treatment was applied to the Group 1. Group 2 and 3 consisted 6th hour control and N-acetylcysteine groups, respectively; whereas Group 4 and 5 were enrolled as the 24th hour control and N-acetylcysteine groups, respectively. Rats were subjected to inhalation of 200 ppm chlorine gas for 20 minutes. Following chlorine gas inhalation, intraperitoneal 40 mg/kg N-acetylcysteine was administered to N-acetylcysteine groups. Same dose of N-acetylcysteine was given again 3 hours later via the same route. Results: While there was no damage in the brain tissue at the 6th hour (p>0.05), there was a damage at the 24th hour (p<0.01). No damage was determined in the heart tissue at 6th and 24th hours (p>0.05). Histologically, N-acetylcysteine was observed to repair the damage in brain tissue which occurred at the 24th hour (p<0.01). Conclusion: Damage occurs in brain tissue at the 24th hour following chlorine gas inhalation. N-acetylcysteine can reduce that damage in experimental animal model.