Akademik Veri Yönetim Sistemi
Jinekoloji ve Obstetrik Dergisi, cilt.16, sa.4, ss.230-233, 2002 (Scopus)
OBJECTIVE: The analgesic efficacy of a prostaglandin synthesis inhibitor piroksikam was tested and compared with petidine HCL in transvaginal oocytes retrieval. STUDY DESIGN: 58 women were admitted for transvaginal oocytes retrieval in invitro fertilization. Womens were randomized in three groups. First group (n = 17) was administred petidine HCL (Aldolan Gerot Pharmazeutika Viyana) 50 mg intramuscularly. The second group received 50 mg petidin intramuscularly and 20 mg piroksikam orally Felden Flash, Pfizer Sandwich Ingiltere). The third group was administred 20 mg piroksikam intramuscularly (Felden IM, Pfizer) Pain intensity during the oocyte aspiration was evaluated by four point scale. 0=no pain, I=tolerable pain, 2=mild pain, 3=intense pain. Statistical analysis was done by Fischer exact probability test. RESULTS: The oocyte retrieval caused no pain in 5 % of cases, tolerable pain in 57 % of cases, mild pain in 28% of cases, intense pain in % 10 of cases. The pain scores were significantly higher in piroksikam intramuscular administered group compared to group 1 and 2. These scores were significantly different statisticaly (p=0.035). The analgesic effect of intramuscular piroksicam is weaker than the petidine during the oocyte aspiration. The additional oral piroksikam to petidine showed neither synergistic nor additive effect in terms of pain relief. CONCLUSION: In the majority of cases 50 mg intramuscular petidine administration produced sufficient analgesia during the oocyte aspiration where circumstances did not allowed general anesthesia. The use of piroksikam instead of narcotic attalgesic agent like pethidine wasn't a good alterantive. When petidine wasn't effective neuroleptic analgesic or general anestesic agents are required.