Lack of association between the 308GA polymorphism of the tumor necrosis factor alpha gene and temporomandibular dysfunction
Pain Clinic, cilt.18, sa.2, ss.175-180, 2006 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 2
- Basım Tarihi: 2006
- Doi Numarası: 10.1163/156856906776760443
- Dergi Adı: Pain Clinic
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.175-180
- Anahtar Kelimeler: Temporomandibular dysfunction, TNF-α and TNF-α-308GA polymorphism
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Objective: To assess whether a relationship exists between G308A polymorphism of TNF-α gene and the temporomandibular dysfunction (TMD). Methods: 98 patients with temporomandibular dysfunction, and 132 healthy volunteer controls were included in the study. Molecular analysis of the G308A polymorphism of TNF-α gene was performed using PCR technique. Results: The ages and genders of the patients and controls were similar (Fisher exact test p = 0.5). There was no relationship between TNF 308GA polymorphism and TMD (χ2 = 4.24, p = 0.12). The allele frequencies of the patients and controls were similar (χ2 = 3.25, p = 0.076). © 2006 VSP.