Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

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Sokmen B. B., Aydin G., Gumus A., Karadeniz S., Ugras H. I., Yanardag R., ...Daha Fazla

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.28, sa.4, ss.870-875, 2013 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 28 Sayı: 4
• Basım Tarihi: 2013
• Doi Numarası: 10.3109/14756366.2012.692086
• Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.870-875
• Anahtar Kelimeler: 4-alkylaminomethyl substituted dihydroxy coumarin derivatives, antioxidant activity, radical scavenging activity, antielastase activity, ANTIINFLAMMATORY ACTIVITY, BIOLOGICAL-ACTIVITY, ELASTASE ACTIVITY, DERIVATIVES, INHIBITORS, HIV, CAPACITY
• İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picrylhydrazil (DPPH.) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.