Anti-angiogenic effect of a Palladium(II)-Saccharinate Complex of Terpyridine in vitro and in vivo

Ikitimur-Armutak E. İ., Gurel-Gurevin E., Kiyan H. T., Aydinlik S., Yilmaz V. T., Dimas K., ...Daha Fazla

MICROVASCULAR RESEARCH, cilt.109, ss.26-33, 2017 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.mvr.2016.09.002
  • Dergi Adı: MICROVASCULAR RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.26-33
  • Anahtar Kelimeler: Palladium(II)-Saccharinate Complex of, Terpyridine, Anti-angiogenic, Chick chorioallantoic membrane (CAM) assay, MTT assay, Tube formation assay, CHORIOALLANTOIC MEMBRANE, PLATINUM(II) COMPLEXES, CYTOTOXIC ACTIVITY, CANCER, ANTITUMOR, CHEMOTHERAPY, ANTIFUNGAL, MODEL
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Anti-angiogenic activity of palladium (Pd) (II)-based complexes is unknown despite their quite powerful anticancer activity. This study was therefore carried out to evaluate both in vivo anti-angiogenic effect and in vitro cytotoxic activity of a Pd(II)-based complex. ([Pd(sac)(terpy)](sac).4H(2)O(sac = saccharinate and terpy = 2,2':6',2 ''-terpyridine)) on HUVEC cells.