The impact of demographics on organ damage in Behçet's syndrome: A cross-sectional analysis of the international PROBE cohort

Floris, Alberto; Laconi, Riccardo; Chadli, Sarra; Laymouna, Ahmed; Hegazy, Mohamed; YAĞIZ ÖZOĞUL, YELİZ; ÖZGÜLER, YEŞİM; Serpa Pinto, Luísa; Alikhani, Majid; Oliveira, Natalia; Sota, Jurgen; Lopalco, Giuseppe; Carboni, Pietro; Poddighe, Dimitri; Kougkas, Nikolaos; Khabbazi, Alireza; De Souza, Alexandre; Lo Monaco, Andrea; Espinosa, Gerard; Butendieck, Ronald; Govoni, Marcello; Issayeva, Bakytsholpan; Iannone, Florenzo; Fabiani, Claudia; Cantarini, Luca; Shahram, Farhad; Araújo Correia, João; Tazi Mezalek, Zoubida; Ragab, Gaafar; Arnaud, Laurent; Cauli, Alberto; Hatemi, GÜLEN; Piga, Matteo; Avgerou, Paraskevi; Akhlaghi, Massoomeh; Faezi, Seyedeh; Filho, Faustino

doi:10.1093/rheumatology/keaf636

The impact of demographics on organ damage in Behçet's syndrome: A cross-sectional analysis of the international PROBE cohort

Floris A., Laconi R., Chadli S., Laymouna A., Hegazy M. T., YAĞIZ ÖZOĞUL Y., ...Daha Fazla

Rheumatology, cilt.65, sa.2, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 65 Sayı: 2
Basım Tarihi: 2026
Doi Numarası: 10.1093/rheumatology/keaf636
Dergi Adı: Rheumatology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
Anahtar Kelimeler: age, Behçet's syndrome, damage, education, geographic variability, sex
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective To examine the influence of demographics on organ damage in a broad, multiethnic cohort of patients with Behçet's syndrome (BS). Methods In this cross-sectional ancillary analysis of the PROBE project, the investigated demographic variables were sex, age, education level and geographic area of residence. Damage was measured by the BS Overall Damage Index (BODI). Multivariate linear (β) and logistic (adjusted odds ratio [adjOR]) regression analyses examined associations between demographics and the extent and prevalence of damage. Results A total of 970 patients were enrolled. The median (interquartile range) age was 40 (31-50) years; 56.5% were males; 21.4% had a low level of education. The median BODI score was 1 (0-3), with 65.6% of patients having a BODI ≥1. Males had higher damage (β 0.103) and a higher prevalence of total (adjOR 1.7, per 10 years), ocular (adjOR 1.6), and vascular (adjOR 2.1) damage. Age was associated with greater damage (β 0.104), and a higher prevalence of overall (adjOR 1.4), neuropsychiatric (adjOR 1.2) and miscellaneous (adjOR 2.0) damage. Low education was associated with a greater frequency of overall (adjOR 1.9) and ocular (adjOR 1.6) damage. North African patients experienced greater damage than South European (β 0.400) and Middle Eastern (β 0.314) patients, as well as a higher risk of overall damage (adjOR 13.9 and 10.7, respectively) across all organ domains, except for the reproductive and gastrointestinal systems. Conclusions This study demonstrates how the extent, prevalence and characteristics of damage in BS vary with demographic factors, underscoring their importance in research and personalized management.