Clinical and forensic evaluation of 66 cases of alcohol intoxication: Insights into substitute alcohols detected by HS-GC/MS


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Bulut C., Arslan Z., Aydoğdu M., Kartufan F. F., Türkmen Z.

FORENSIC SCIENCE INTERNATIONAL. AN INTERNATIONAL JOURNAL DEDICATED TO THE APPLICATIONS OF GENETICS IN THE ADMINISTRATION OF JUSTICE, cilt.379, ss.112764, 2026 (SCI-Expanded, Scopus) identifier identifier identifier identifier

Özet

Rising global alcohol consumption is a major public health and safety concern. Over the last decade, undeclared alcohol consumption has increasingly come into focus due to high inflation that has led many individuals to resort to unhealthy methods to access alcohol. In this context, the development of methods for alcohol detection in biological samples is of great importance in terms of rapid diagnosis, effective treatment, and obtaining reliable evidence in forensic processes. In this study, an HS-GC/MS method for the evaluation of alcohol intoxication in blood samples was developed and validated. The validated method was applied to 66 patients (57 males, 9 females) who were diagnosed with alcohol intoxication due to consumption of counterfeit alcoholic beverages. Of these cases, only one type of alcohol (ethanol n = 20, methanol n = 7, 2-propanol n = 1, acetone n = 2) was detected in 30 patients, more than two types of alcohol were detected in 19 patients, and 17 patients had negative results. Out of 66 patients, two patients died, and the alcohol concentrations obtained from the patients ranged from 1.2 mg/dL to 597.0 mg/dL. This study highlights the dangers of undeclared alcohol use and the importance of a new detection method developed to accurately assess alcohol intoxication in emergencies.